RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
腹横肌平面阻滞联合小剂量右美托咪定对接受腹腔镜结肠切除术老年患者的影响
英文原题：Effect of transversus abdominis plane block combined with low-dose dexmedetomidine on elderly patients undergoing laparoscopic colectomy.
查看英文原题
Effect of transversus abdominis plane block combined with low-dose dexmedetomidine on elderly patients undergoing laparoscopic colectomy.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
研究概要
TAPB 联合低剂量右美托咪定可发挥更好的麻醉、镇痛和镇静效果，并减轻应激反应。
中文摘要
目的
评估腹横肌平面阻滞（TAPB）联合低剂量右美托咪定对接受腹腔镜结肠切除术老年患者的影响。
材料与方法
采用随机双盲方法，将2021年3月至2022年3月接受腹腔镜结肠切除术的62例老年患者随机等分为A组（低剂量右美托咪定）和B组（TAPB联合低剂量右美托咪定），比较治疗结局。
结果
术后6小时及第1、2、3天，B组静息和活动状态视觉模拟量表评分及匹兹堡睡眠质量指数均低于A组（p<0.05）。麻醉前两组CD4+、CD8+和游离皮质醇水平、CD4+/CD8+比值及NK细胞水平无显著差异（p>0.05）。术后24小时，B组CD4+、CD4+/CD8+比值和NK细胞水平均高于A组，CD8+及游离皮质醇水平则更低（p<0.05）。B组氧分压和pH较高[分别为45.52±11.14 mmHg和7.42±0.06]，二氧化碳分压较低[4.05±0.32 mmHg]（均p<0.05）。
结论
TAPB联合低剂量右美托咪定可获得更好的麻醉、镇痛和镇静效果，并改善应激反应。
展开英文摘要原文
RESULTS
The resting and active Visual Analogue Scale and Pittsburgh Sleep Quality Index scores were lower in Group B than those in Group A at 6 h, 1 day, 2 days and 3 days after operation (p < 0.05). The two groups had no significant differences in the levels of cluster of differentiation 4+ (CD4+), CD8+ and free Cor, CD4+/CD8+ ratio and NK cell level before anesthesia (p > 0.05). At 24 h after the operation, the level of CD4+, CD4+/CD8+ ratio and NK cell level were higher in Group B than those in Group A, and the levels of CD8+ and free Cor were lower in Group B (p < 0.05). Group B had higher partial pressure of oxygen ((45.52 11.14) mm Hg) and pH (7.42 0.06) (p < 0.05) and lower partial pressure of carbon dioxide ((4.05 0.32) mm Hg) than those of Group A (p < 0.05).
CONCLUSIONS
TAPB combined with low-dose dexmedetomidine can exert better anesthetic, analgesic and sedative effects, and ameliorate stress responses.
论文信息
- 作者
- Zhang Z、Hao D
- 单位
- Department of Anesthesiology, Jaozuo People's Hospital, Jaozuo, Henan Province, China.China
- 期刊
- Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques2023 Sep
- 原文标识
- PubMed 37868283 · DOI 10.5114/wiitm.2023.128713
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