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癌症免疫治疗中前景广阔的领域:溶瘤病毒

英文原题:A promising future in cancer immunotherapy: Oncolytic viruses.

查看英文原题

A promising future in cancer immunotherapy: Oncolytic viruses.

PubMed 2023/10/04(内容时间) Eur J Pharmacol Q1 · IF 5.7(JCR 2025)

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中文摘要

除传统疗法外,基于免疫治疗的方法也日益受到关注。免疫疗法已成为治疗肿瘤的一种选择,具有更高特异性并可能改善疗效,可增强或调节免疫系统,从而配合靶向病毒治疗。溶瘤病毒疗法是一类溶瘤免疫治疗,近几十年来因具有多种优势而在癌症治疗中受到广泛研究。随着对癌细胞生物学及肿瘤发生机制的认识不断深入,也随着对条件复制型溶瘤病毒及其破坏肿瘤细胞功能的了解增加,目前已能够将这一策略用于恶性肿瘤治疗。根据溶瘤病毒临床试验取得的成果,有理由期待这类治疗在癌症治疗中发挥更核心的作用。未来,将溶瘤病毒与标准癌症治疗及其他免疫疗法联合,有望获得更佳疗效。

展开英文摘要原文

Alongside the conventional methods, attention has been drawn to the use of immunotherapy-based methods for cancer treatment. Immunotherapy has developed as a therapeutic option that can be more specific with better outcomes in tumor treatment. It can boost or regulate the immune system behind the targeted virotherapy. Virotherapy is a kind of oncolytic immunotherapy that investigated broadly in cancer treatment in recent decades, due to its several advantages.

According to recent advance in the field of understanding cancer cell biology and its occurrence, as well as increasing the knowledge about conditionally replicating oncolytic viruses and their destructive function in the tumor cells, nowadays, it is possible to apply this strategy in the treatment of malignancies.

Relying on achievements in clinical trials of oncolytic viruses, we can certainly expect that this therapeutic perception can play a more central role in cancer treatment. In cancer treatment, combination therapy using oncolytic viruses alongside standard cancer treatment methods and other immunotherapy-based treatments can expect more promising results in the future.

论文信息

作者
Seyed-Khorrami SM、Azadi A、Rastegarvand N、Habibian A、Soleimanjahi H、Łos MJ
第一作者单位
Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.Iran
通讯作者单位
Biotechnology Center, Silesian University of Technology, 8 Krzywousty St., 44-100, Gliwice, Poland; LinkoCare Life Sciences AB, Linkoping, Sweden. Electronic address: marek.los@polsl.pl.Poland
期刊
European journal of pharmacology2023 Dec 5
原文标识
PubMed 37797673 · DOI 10.1016/j.ejphar.2023.176063