CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Mesenchymal stem cells and ovarian cancer: Is there promising news?
Mesenchymal stem cells and ovarian cancer: Is there promising news?
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卵巢癌（OC）是一种异质性强、病情复杂的疾病，死亡率高、预后不佳，且常在晚期确诊。OC 可依据来源和组织病理学等不同指标划分为多个亚组。目前 OC 治疗包括手术后联合化疗和放疗，但这些方法会产生多种副作用，对 OC 的疗效也不够理想。近年来，间充质干细胞（MSC）疗法受到关注，并被用于治疗包括癌症在内的多种疾病。MSC 是多能干细胞，可从脐带、脂肪组织、骨髓和胎盘等不同来源获得，其治疗 OC 的效果已有研究。本叙述性综述旨在回顾并讨论目前有关不同来源 MSC 对 OC 影响的研究，特别关注其中涉及的作用机制。
Ovarian cancer (OC) is described as a heterogeneous complex condition with high mortality, weak prognosis, and late-stage presentation. OC has several subgroups based on different indices, like the origin and histopathology. The current treatments against OC include surgery followed by chemotherapy and radiotherapy; however, these methods have represented diverse side effects without enough effectiveness on OC.
Recently, mesenchymal stem cell (MSC)-based therapy has acquired particular attention for treating diverse problems, such as cancer. These multipotent stem cells can be obtained from different sources, such as the umbilical cord, adipose tissues, bone marrow, and placenta, and their efficacy has been investigated against OC. Hence, in this narrative review, we aimed to review and discuss the present studies about the effects of various sources of MSCs on OC with a special focus on involved mechanisms.
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