CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
增强 HIV 感染中 CAR-T 细胞扩增与持续存在的策略
英文原题：Strategies for enhancing CAR T cell expansion and persistence in HIV infection.
查看英文原题
Strategies for enhancing CAR T cell expansion and persistence in HIV infection.
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中文摘要
嵌合抗原受体（CAR）T 细胞疗法治疗血液系统恶性肿瘤取得了巨大成功，也作为 HIV 治疗乃至治愈策略显示出良好前景。CAR-T 细胞疗效的重要决定因素之一是细胞持久性；抗原密度和靶细胞丰度尤其影响 CAR-T 细胞的结合、植入和持久性。HIV 特异性 CAR-T 细胞的成功受到抗原有限的阻碍，其原因包括病毒蛋白在细胞表面表达较低，以及抗逆转录病毒治疗期间慢性感染细胞数量少。研究人员已探索多种策略，通过增强工程化细胞扩增和持久性来提高 CAR-T 疗效。本综述介绍设计靶向 HIV 及其他慢性病毒感染的 CAR-T 细胞时面临的挑战，并讨论在抗原暴露低的情况下增强 CAR-T 细胞扩增和持久性的潜在策略。
展开英文摘要原文
Chimeric Antigen Receptor (CAR) T cell therapies are tremendously successful in hematological malignancies and show great promise as treatment and curative strategy for HIV. A major determinant for effective CAR T cell therapy is the persistence of CAR T cells. Particularly, antigen density and target cell abundance are crucial for the engagement, engraftment, and persistence of CAR T cells.
The success of HIV-specific CAR T cells is challenged by limited antigen due to low cell surface expression of viral proteins and the scarcity of chronically infected cells during antiretroviral therapy. Several strategies have been explored to increase the efficacy of CAR T cells by enhancing expansion and persistence of the engineered cells. This review highlights the challenges of designing CAR T cells against HIV and other chronic viral infections.
We also discuss potential strategies to enhance CAR T cell expansion and persistence in the setting of low antigen exposure.
论文信息
- 作者
- Rothemejer FH、Lauritsen NP、Søgaard OS、Tolstrup M
- 单位
- Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.Denmark
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2023
- 原文标识
- PubMed 37671164 · DOI 10.3389/fimmu.2023.1253395
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