CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
RAS 信号传导与免疫细胞：肿瘤微环境中的险恶串扰
英文原题：RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment.
查看英文原题
RAS signaling and immune cells: a sinister crosstalk in the tumor microenvironment.
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中文摘要
鼠肉瘤病毒（RAS）基因是癌症中最常见的突变癌基因，约19%的癌症患者携带RAS突变。近年来，关于RAS突变与肿瘤免疫微环境（TIM）相互作用的研究蓬勃发展。越来越多的证据证明，RAS信号在调节免疫细胞的募集、活化和分化的同时，还协助肿瘤细胞逃避免疫监视。本综述总结了针对RAS突变的直接和间接治疗策略。此外，我们更新了RAS信号调控免疫浸润和免疫逃逸的潜在机制。最后，我们讨论了RAS靶向免疫治疗的研究进展，包括癌症疫苗和过继性细胞疗法，特别关注与个性化治疗的联合策略以及实现持久临床获益的巨大潜力。
展开英文摘要原文
The rat sarcoma virus (RAS) gene is the most commonly mutated oncogene in cancer, with about 19% of cancer patients carrying RAS mutations. Studies on the interaction between RAS mutation and tumor immune microenvironment (TIM) have been flourishing in recent years. More and more evidence has proved that RAS signals regulate immune cells' recruitment, activation, and differentiation while assisting tumor cells to evade immune surveillance. This review concluded the direct and indirect treatment strategies for RAS mutations.
In addition, we updated the underlying mechanisms by which RAS signaling modulated immune infiltration and immune escape.
Finally, we discussed advances in RAS-targeted immunotherapies, including cancer vaccines and adoptive cell therapies, with a particular focus on combination strategies with personalized therapy and great potential to achieve lasting clinical benefits.
论文信息
- 作者
- Liu Y、Xie B、Chen Q
- 第一作者单位
- Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.China
- 通讯作者单位
- Department of Geriatrics, Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China. qiongch@csu.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Journal of translational medicine2023 Sep 5
- 原文标识
- PubMed 37670322 · DOI 10.1186/s12967-023-04486-9
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