CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗：非计划急诊就诊的前瞻性观察性研究
英文原题：Chimeric antigen receptor T-cell therapy: Prospective observational study of unplanned emergency department presentations.
查看英文原题
Chimeric antigen receptor T-cell therapy: Prospective observational study of unplanned emergency department presentations.
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研究概要
如果 CAR-T 疗法要更广泛地应用，尤其是在门诊诊疗模式下，就需要标准化的急诊科诊疗模式以识别特定的并发症。
中文摘要
目的
CAR-T（CAR-T）细胞疗法是治疗难治性血液系统恶性肿瘤的新兴方法。CAR-T 治疗后患者计划外前往急诊科（ED），越来越突显了建立整合照护模式的必要性，以便及早识别 CAR-T 特异性并发症。
方法
本研究为在三级医疗中心开展的前瞻性观察研究。治疗医师将全部 CAR-T 患者（n = 17）纳入研究登记，并由研究人员进行标记，使患者在 ED 分诊时触发 CAR-T 信息警示弹窗。研究人员回顾病历，评估 90 天内计划外就诊、并发症和患者结局。
结果
CAR-T 患者常在治疗后 7 天内出现毒性，通常较轻，并发生于住院期间。病历审查发现 5 次计划外 ED 就诊，这些就诊被识别为 CAR-T 治疗后情况，但不能直接归因于特定毒性。
结论
若 CAR-T 治疗将更广泛使用，尤其是在门诊照护模式下，就需要标准化急诊照护模式，以识别特定并发症。
展开英文摘要原文
OBJECTIVE
Chimeric antigen receptor T-cell (CAR-T) therapy is an emerging treatment for refractory hematologic malignancy. Unplanned ED presentations following CAR-T present the increasing need for an integrated model of care that allows for the early recognition of its specific complications.
METHODS
This is a prospective observational study at a tertiary centre. CAR-T patients (n = 17) were universally enrolled into a study registry by treating providers. These patients were flagged by investigators to trigger a pop-up notification CAR-T information warning at ED triage. Medical records were reviewed 90 days for unplanned presentations, complications and patient-oriented outcomes.
RESULTS
Patients receiving CAR-T frequently encountered toxicity within 7 days of therapy. This was typically mild and occurred in an inpatient setting. Medical record review revealed five unplanned ED presentations (that were recognised as post CAR-T) and not directly attributable to specific toxicities.
CONCLUSION
If CAR-T therapy is to be used more widely especially in an outpatient model of care, a standardised ED model of care for recognition of specific complications is needed.
论文信息
- 作者
- Bak GG、Micklethwaite K、Maddock K、Coggins A
- 第一作者单位
- Department of General Medicine, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.Australia
- 通讯作者单位
- Simulated Learning Environment for Clinical Training, Westmead Hospital, Sydney, New South Wales, Australia.Australia
- 文献类型
- 观察性研究
- 期刊
- Emergency medicine Australasia : EMA2023 Dec
- 原文标识
- PubMed 37669879 · DOI 10.1111/1742-6723.14300