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细胞因子释放综合征中的可成药靶点

英文原题:Druggable Targets in Cytokine Release Syndromes.

查看英文原题

Druggable Targets in Cytokine Release Syndromes.

PubMed 2023/11/01(内容时间) Clin Cancer Res Q1 · IF 10.9(JCR 2025)

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中文摘要

双特异性T细胞衔接器和CAR-T 细胞共同面临引发急性全身性炎症发作的问题,即细胞因子释放综合征。了解可被临床可用药物中和的细胞因子序贯波次,对于在不影响抗肿瘤治疗结局的前提下预防或治疗这一状况至关重要。参见Leclercq-Cohen等人的相关文章,第4449页。

展开英文摘要原文

Bispecific T-cell engagers and chimeric antigen receptor T cells share the problem of eliciting acute systemic inflammation episodes known as cytokine release syndrome. Knowledge on the sequential waves of cytokines that can be neutralized with clinically available agents is crucial to prevent or treat this condition without jeopardizing the antitumor therapeutic outcome. See related article by Leclercq-Cohen et al., p. 4449.

论文信息

作者
Luri-Rey C、Eguren-Santamaria I、Matos I、Berraondo P、Melero I
单位
Program of Immunology and Immunotherapy, CIMA Universidad de Navarra, Pamplona, Spain.Spain
文献类型
非美国政府资助研究 · 评论
期刊
Clinical cancer research : an official journal of the American Association for Cancer Research2023 Nov 1
原文标识
PubMed 37656058 · DOI 10.1158/1078-0432.CCR-23-1975