CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Druggable Targets in Cytokine Release Syndromes.
Druggable Targets in Cytokine Release Syndromes.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
双特异性T细胞衔接器和CAR-T 细胞共同面临引发急性全身性炎症发作的问题,即细胞因子释放综合征。了解可被临床可用药物中和的细胞因子序贯波次,对于在不影响抗肿瘤治疗结局的前提下预防或治疗这一状况至关重要。参见Leclercq-Cohen等人的相关文章,第4449页。
Bispecific T-cell engagers and chimeric antigen receptor T cells share the problem of eliciting acute systemic inflammation episodes known as cytokine release syndrome. Knowledge on the sequential waves of cytokines that can be neutralized with clinically available agents is crucial to prevent or treat this condition without jeopardizing the antitumor therapeutic outcome. See related article by Leclercq-Cohen et al., p. 4449.
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