CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Immunotherapy: cancer immunotherapy and its combination with nanomaterials and other therapies.
Immunotherapy: cancer immunotherapy and its combination with nanomaterials and other therapies.
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免疫治疗是继手术治疗、放射治疗和化学治疗之后的一种新型肿瘤治疗方法,可以通过激活或增强免疫反应来管理和摧毁肿瘤细胞。与传统治疗方法相比,免疫治疗具有复发率低和特异性高的优势。近年来,免疫治疗发展迅速,已成为研究热点。目前,CAR-T 细胞免疫治疗和免疫检查点抑制剂是临床实践中最为有效的肿瘤免疫治疗方法。虽然肿瘤免疫治疗为患者带来了希望,但也面临一些挑战,仍需不断研究和进步。联合治疗是抗肿瘤治疗的未来方向。在本综述中,主要关注免疫检查点抑制剂、细胞疗法、肿瘤疫苗、小分子抑制剂和溶瘤病毒疗法在肿瘤治疗中的研究进展概述,以及免疫治疗与其他治疗的联合应用。
Immunotherapy is a new type of tumor treatment after surgery, radiotherapy and chemotherapy, and can be used to manage and destroy tumor cells through activating or strengthening the immune response. Immunotherapy has the benefits of a low recurrence rate and high specificity compared to traditional treatment methods. Immunotherapy has developed rapidly in recent years and has become a research hotspot. Currently, chimeric antigen receptor T-cell immunotherapy and immune checkpoint inhibitors are the most effective tumor immunotherapies in clinical practice.
While tumor immunotherapy brings hope to patients, it also faces some challenges and still requires continuous research and progress. Combination therapy is the future direction of anti-tumor treatment. In this review, the main focus is on an overview of the research progress of immune checkpoint inhibitors, cellular therapies, tumor vaccines, small molecule inhibitors and oncolytic virotherapy in tumor treatment, as well as the combination of immunotherapy with other treatments.
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