CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
革新肿瘤治疗：CAR-T 细胞治疗综合综述
英文原题：Revolutionizing cancer treatment: a comprehensive review of CAR-T cell therapy.
查看英文原题
Revolutionizing cancer treatment: a comprehensive review of CAR-T cell therapy.
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中文摘要
嵌合抗原受体（CAR）T 细胞疗法是一种有前景的新型癌症治疗方法，通过基因改造患者的 T 细胞，使其识别并攻击癌细胞。本综述概述了 CAR-T 细胞疗法的最新发现和临床试验，并介绍该疗法的概念与应用。文章还讨论 CAR-T 细胞疗法的局限性和潜在副作用，包括费用高昂以及细胞因子释放综合征和神经毒性的风险。CAR-T 细胞疗法在治疗血液系统恶性肿瘤方面显示出良好结果，但仍需持续研究以改善疗效和安全性，并扩大其在实体瘤中的应用。随着研究和开发不断推进，CAR-T 细胞疗法有望变革癌症治疗并改善患者结局。
展开英文摘要原文
Chimeric antigen receptor (CAR)-T cell therapy is a promising new treatment for cancer that involves genetically modifying a patient's T-cells to recognize and attack cancer cells. This review provides an overview of the latest discoveries and clinical trials related to CAR-T cell therapy, as well as the concept and applications of the therapy. The review also discusses the limitations and potential side effects of CAR-T cell therapy, including the high cost and the risk of cytokine release syndrome and neurotoxicity.
While CAR-T cell therapy has shown promising results in the treatment of hematologic malignancies, ongoing research is needed to improve the efficacy and safety of the therapy and expand its use to solid tumors. With continued research and development, CAR-T cell therapy has the potential to revolutionize cancer treatment and improve outcomes for patients with cancer.
论文信息
- 作者
- Dabas P、Danda A
- 单位
- St Jude Children's Research Hospital, Memphis, TN, USA. preeti.dabas3@gmail.com.United States
- 文献类型
- 综述
- 期刊
- Medical oncology (Northwood, London, England)2023 Aug 22
- 原文标识
- PubMed 37608202 · DOI 10.1007/s12032-023-02146-y