CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
探索髓母细胞瘤的分子复杂性：对诊断和治疗的意义
英文原题：Exploring the Molecular Complexity of Medulloblastoma: Implications for Diagnosis and Treatment.
查看英文原题
Exploring the Molecular Complexity of Medulloblastoma: Implications for Diagnosis and Treatment.
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中文摘要
髓母细胞瘤是儿童最常见的恶性脑肿瘤。过去几十年间，对该病关键分子基础的认识取得重大进展，鉴定出具有不同临床结局的分子亚组。本综述更新髓母细胞瘤分子图谱和治疗策略，讨论四个主要分子亚组（WNT活化型、SHH活化型以及非WNT/非SHH的第3组和第4组），重点介绍各亚型相关的关键基因改变和信号通路。此外，文章探讨表观遗传调节在髓母细胞瘤中的新兴作用及治疗耐药机制，并介绍靶向治疗和免疫治疗的最新进展。仍需持续开展协作研究，以进一步揭示该病复杂分子机制并制定最佳治疗方案。
展开英文摘要原文
Medulloblastoma is the most common malignant brain tumor in children. Over the last few decades, significant progress has been made in revealing the key molecular underpinnings of this disease, leading to the identification of distinct molecular subgroups with different clinical outcomes. In this review, we provide an update on the molecular landscape of medulloblastoma and treatment strategies.
We discuss the four main molecular subgroups (WNT-activated, SHH-activated, and non-WNT/non-SHH groups 3 and 4), highlighting the key genetic alterations and signaling pathways associated with each entity.
Furthermore, we explore the emerging role of epigenetic regulation in medulloblastoma and the mechanism of resistance to therapy.
We also delve into the latest developments in targeted therapies and immunotherapies. Continuing collaborative efforts are needed to further unravel the complex molecular mechanisms and profile optimal treatment for this devastating disease.
论文信息
- 作者
- Rechberger JS、Toll SA、Vanbilloen WJF、Daniels DJ、Khatua S
- 第一作者单位
- Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.United States
- 通讯作者单位
- Department of Pediatric Hematology/Oncology, Section of Neuro-Oncology, Mayo Clinic, Rochester, MN 55905, USA.United States
- 文献类型
- 综述
- 期刊
- Diagnostics (Basel, Switzerland)2023 Jul 18
- 原文标识
- PubMed 37510143 · DOI 10.3390/diagnostics13142398
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