CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
B 淋巴细胞白血病 CAR-T 细胞治疗的现状
英文原题：The Current State of Chimeric Antigen Receptor T Cell Therapy for B Lymphoblastic Leukemia.
查看英文原题
The Current State of Chimeric Antigen Receptor T Cell Therapy for B Lymphoblastic Leukemia.
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中文摘要
在过去十年中，CAR-T 细胞疗法已经改变了儿童和成人复发/难治性B-ALL的治疗。CD19靶向的CAR-T 细胞可以使大多数B-ALL患者获得完全缓解，其中多达一半的患者将继续维持持久缓解。然而，对于复发或无应答的患者，仍存在重大挑战。本综述将讨论CAR-T 细胞疗法治疗B-ALL的历史、CAR-T 细胞接受者的治疗考虑，以及当前临床试验和CAR-T 细胞疗法在B-ALL中的未来方向。
展开英文摘要原文
Over the past decade, CAR T cell therapy has transformed the treatment of relapsed or refractory B-ALL in children and adults. CD19-directed CAR T cells can induce complete remissions in a large majority of patients with B-ALL, and up to half of these patients will go on to maintain durable remissions.
However, significant challenges remain for patients who relapse or do not respond. This review will discuss the history of CAR T cell therapy for B-ALL, the treatment considerations for CAR T cell recipients, and current clinical trials and future directions for CAR T cell therapy in B-ALL.
论文信息
- 作者
- McClory SE、Maude SL
- 第一作者单位
- Division of Oncology, Cancer Immunotherapy Program, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.United States
- 通讯作者单位
- Division of Oncology, Cancer Immunotherapy Program, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: maude@chop.edu.United States
- 文献类型
- 综述
- 期刊
- Hematology/oncology clinics of North America2023 Dec
- 原文标识
- PubMed 37500380 · DOI 10.1016/j.hoc.2023.06.003