免疫检查点阻断通过扩增效应 CD8⁺ T 细胞克隆增强淋巴细胞清除性化疗诱导的抗肿瘤免疫
Immune Checkpoint Blockade Augments Lymphodepleting Chemotherapy-Induced Antitumor Immunity by Expanding Effector CD8+ T-cell Clones.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Perspectives in Immunotherapy: meeting report from Immunotherapy Bridge (Naples, November 30th-December 1st, 2022).
Perspectives in Immunotherapy: meeting report from Immunotherapy Bridge (Naples, November 30th-December 1st, 2022).
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利用患者免疫系统并防止免疫逃逸的新型治疗方法的发现和开发,显著改善了各类癌症患者的预后。然而,并非所有患者都对免疫治疗产生应答,获得性耐药仍然是一个挑战,且在某些被认为是免疫冷肿瘤的肿瘤中应答较差。这促使人们需要新的基于免疫治疗的方法,包括过继细胞转移(ACT)、治疗性疫苗和新型免疫检查点抑制剂。这些新方法聚焦于对当前治疗应答不充分患者,新出现的证据表明,新型免疫治疗药物(通常与现有药物联合使用)在多种癌症中改善了应答。细胞疗法的使用、免疫应答的驱动因素以及免疫治疗的趋势是Immunotherapy Bridge(2022年11月30日至12月1日)的焦点,该会议由意大利那不勒斯的Fondazione Melanoma Onlus与癌症免疫治疗学会合作组织。
The discovery and development of novel treatments that harness the patient's immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types.
However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors.
These new approaches are focused on patients with an inadequate response to current treatments, with emerging evidence of improved responses in various cancers with new immunotherapy agents, often in combinations with existing agents. The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer.
在 PubMed 查看 → 出版商原文(DOI) 全文 PDF(PMC)· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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