CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
无法摆脱 MIC(A/B)：阻止应激配体脱落以增强泛癌靶向
英文原题：Can't drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting.
查看英文原题
Can't drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting.
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中文摘要
基于嵌合抗原受体（CAR）的细胞疗法在血液系统恶性肿瘤中取得了显著成功，但其在实体瘤中的应用仍面临挑战。在本期，Goulding等人1描述了一种独特的CAR自然杀伤（NK）细胞平台，通过保留和识别肿瘤细胞膜上的应激配体，具有泛癌活性。
展开英文摘要原文
Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al. 1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.
论文信息
- 作者
- Lakes N、Canaday LM、Waggoner SN
- 第一作者单位
- Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.United States
- 通讯作者单位
- Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: stephen.waggoner@cchmc.org.United States
- 文献类型
- 评论
- 期刊
- Med (New York, N.Y.)2023 Jul 14
- 原文标识
- PubMed 37453414 · DOI 10.1016/j.medj.2023.06.009