← 返回

CAR-T 细胞治疗的未来

英文原题:The Future of Chimeric Antigen Receptor T Cell Therapy.

查看英文原题

The Future of Chimeric Antigen Receptor T Cell Therapy.

PubMed 2023/07/11(内容时间) Hematol Oncol Clin North Am Q2 · IF 3.1(JCR 2025)

分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。

中文摘要

在过去10年中,CAR-T 细胞疗法已显示出对B细胞和浆细胞恶性肿瘤的变革性作用,然而该领域才刚刚开始认识到此类疗法对患者的潜在益处。在未来10年中,预计将在以下方面取得进展:B细胞/浆细胞恶性肿瘤患者的持久缓解率;扩展至T细胞、髓系和实体恶性肿瘤;以及通过递送和制造变革该领域。

展开英文摘要原文

Over the last 10 years CAR T cell therapies have been shown to be transformative for B- and plasma-cell malignancies, however the field is only beginning to realize the potential benefit to patients of such therapies. Over the next 10 years it is expected that advances will be made in durable response rates for patients with B/plasma cell malignancies; expansion to T-cell, myeloid, and solid malignancies; and in delivery and manufacturing to transform the field.

论文信息

作者
Smith EL
单位
Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: EricL_Smith@dfci.harvard.edu.United States
文献类型
综述 · 美国 NIH 资助研究 · 非美国政府资助研究
期刊
Hematology/oncology clinics of North America2023 Dec
原文标识
PubMed 37442674 · DOI 10.1016/j.hoc.2023.06.005