CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:The Future of Chimeric Antigen Receptor T Cell Therapy.
The Future of Chimeric Antigen Receptor T Cell Therapy.
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在过去10年中,CAR-T 细胞疗法已显示出对B细胞和浆细胞恶性肿瘤的变革性作用,然而该领域才刚刚开始认识到此类疗法对患者的潜在益处。在未来10年中,预计将在以下方面取得进展:B细胞/浆细胞恶性肿瘤患者的持久缓解率;扩展至T细胞、髓系和实体恶性肿瘤;以及通过递送和制造变革该领域。
Over the last 10 years CAR T cell therapies have been shown to be transformative for B- and plasma-cell malignancies, however the field is only beginning to realize the potential benefit to patients of such therapies. Over the next 10 years it is expected that advances will be made in durable response rates for patients with B/plasma cell malignancies; expansion to T-cell, myeloid, and solid malignancies; and in delivery and manufacturing to transform the field.
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