RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤微环境中 NK 细胞的功能性交互与调控：意义及潜在治疗策略
英文原题：Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies.
查看英文原题
Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies.
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中文摘要
自然杀伤（NK）细胞能消灭多种肿瘤细胞和异常细胞。然而，肿瘤微环境（TME）中的NK细胞常常功能耗竭。少数NK细胞亚群甚至促进肿瘤生长。本研究综述了NK细胞的生物学特性、NK细胞在TME中的动态表型变化，以及NK细胞与其他免疫细胞和非免疫细胞之间的通讯。
展开英文摘要原文
Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells.
However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth.
This study reviewed the biological properties of NK cells, the dynamic phenotypic changes of NK cells in the TME, and the communication between NK cells and other immune and nonimmune cells.
论文信息
- 作者
- Wang L、Chen Z、Liu G、Pan Y
- 单位
- Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430071, China.China
- 文献类型
- 综述
- 期刊
- Genes & diseases2023 May
- 原文标识
- PubMed 37396514 · DOI 10.1016/j.gendis.2022.07.009
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