CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗副作用的影像学检查：执业放射科医师入门指南
英文原题：Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist.
查看英文原题
Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法是一种突破性的免疫疗法，已证实对多种血液系统癌症有效。CAR是经修饰后表达肿瘤相关抗原人工受体的T淋巴细胞。将这些工程化细胞重新输回体内，可增强宿主免疫应答并清除恶性细胞。尽管CAR-T 细胞疗法的应用迅速扩大，但细胞因子释放综合征（CRS）和免疫效应细胞相关神经毒性综合征（ICANS）等常见副作用在影像学上的表现仍鲜为人知。本文全面回顾这些副作用在不同器官系统中的影像表现，以及如何进行最佳影像检查。对放射科医师及患者而言，尽早准确识别这些副作用的影像学表现至关重要，以便及时发现并治疗。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cell therapy is a revolutionary form of immunotherapy that has proven to be efficacious in the treatment of many hematologic cancers. CARs are modified T lymphocytes that express an artificial receptor specific to a tumor-associated antigen.
These engineered cells are then reintroduced to upregulate the host immune responses and eradicate malignant cells. While the use of CAR T cell therapy is rapidly expanding, little is known about how common side effects such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) present radiographically.
Here we provide a comprehensive review of how side effects present in different organ systems and how they can be optimally imaged. Early and accurate recognition of the radiographic presentation of these side effects is critical to the practicing radiologist and their patients so that these side effects can be promptly identified and treated.
论文信息
- 作者
- Huang S、de Jong D、Das JP、Widemon RS、Braumuller B、Paily J、Deng A、Liou C
- 第一作者单位
- Department of Radiology, Columbia University Irving Medical Center, 622 W 168th Street, New York, New York 10032 (S.H., R.S.W., B.B., J.P., C.L., T.R., A.H., H.M., B.D.S., J.L., J.L.H., P.N., L.L., M.F., V.M., L.D., M.S., K.M.C.).United States
- 通讯作者单位
- Department of Radiology, Columbia University Irving Medical Center, 622 W 168th Street, New York, New York 10032 (S.H., R.S.W., B.B., J.P., C.L., T.R., A.H., H.M., B.D.S., J.L., J.L.H., P.N., L.L., M.F., V.M., L.D., M.S., K.M.C.). Electronic address: kmc2113@cumc.columbia.edu.United States
- 文献类型
- 综述
- 期刊
- Academic radiology2023 Nov
- 原文标识
- PubMed 37394411 · DOI 10.1016/j.acra.2023.04.004