CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胶质瘤免疫治疗研究中的转化模型
英文原题：Translational Models in Glioma Immunotherapy Research.
查看英文原题
Translational Models in Glioma Immunotherapy Research.
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中文摘要
免疫疗法是治疗胶质瘤的一种有前景的领域，但多种免疫治疗方式的临床试验尚未显著改善患者生存。胶质瘤临床前模型应忠实呈现临床观察到的肿瘤行为、突变负荷、肿瘤与基质细胞相互作用及免疫抑制机制。本综述介绍胶质瘤免疫学研究中常用的临床前模型，讨论其优势和不足，并举例说明这些模型在转化研究中的应用。
展开英文摘要原文
Immunotherapy is a promising therapeutic domain for the treatment of gliomas.
However, clinical trials of various immunotherapeutic modalities have not yielded significant improvements in patient survival. Preclinical models for glioma research should faithfully represent clinically observed features regarding glioma behavior, mutational load, tumor interactions with stromal cells, and immunosuppressive mechanisms. In this review, we dive into the common preclinical models used in glioma immunology, discuss their advantages and disadvantages, and highlight examples of their utilization in translational research.
论文信息
- 作者
- Ren AL、Wu JY、Lee SY、Lim M
- 第一作者单位
- School of Medicine, Stanford University, Stanford, CA 94305, USA.United States
- 通讯作者单位
- Department of Neurosurgery, Stanford University Medical Center, Stanford, CA 94304, USA.United States
- 文献类型
- 综述
- 期刊
- Current oncology (Toronto, Ont.)2023 Jun 11
- 原文标识
- PubMed 37366911 · DOI 10.3390/curroncol30060428
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