CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
转一转：血液分离术在成人白血病患者护理中的应用
英文原题：Take a spin: Apheresis in the care of adult leukaemia patients.
查看英文原题
Take a spin: Apheresis in the care of adult leukaemia patients.
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中文摘要
血液分离术是一种自动化过程，用于分离患者或供者的全血，采集或去除特定血液成分，并将其余部分回输给个体。血液分离术是血液和骨髓移植的重要组成部分，并越来越多地应用于多种血液疾病的新型细胞疗法中。本综述通过临床病例突出血液分离术在成人白血病患者护理中的多重作用，包括高白细胞血症中的治疗性白细胞分离术、供者中动员外周血造血祖细胞采集、用于供者淋巴细胞输注或CAR-T 细胞制备的单核细胞采集，以及治疗移植物抗宿主病的体外光分离术。
展开英文摘要原文
Apheresis is an automated process to separate the whole blood of a patient or a donor, collect or remove specific blood components, and return the remaining back to the individual. Apheresis is an integral part of blood and marrow transplantation and has been increasingly utilized in novel cellular therapies for a variety of blood disorders.
This review uses clinical cases to highlight the multiple roles of apheresis in the care of adult leukaemia patients, including therapeutic leukapheresis in hyperleukocytosis, mobilized peripheral blood hematopoietic progenitor cell collection in donors, mononucleated cell collection in preparation of donor lymphocyte infusion or chimeric antigen receptor T cells manufacture, and extracorporeal photopheresis in the treatment of graft versus host diseases.
论文信息
- 作者
- Ai J
- 单位
- Transplant and Cellular Therapy Program, Levine Cancer Institute, Atrium Health, 1021 Morehead Medical Drive, LCI 2, Charlotte, NC, 28204, USA. Electronic address: jing.ai@atriumhealth.org.United States
- 文献类型
- 综述
- 期刊
- Best practice & research. Clinical haematology2023 Jun
- 原文标识
- PubMed 37353291 · DOI 10.1016/j.beha.2023.101467