CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
急性白血病移植与细胞治疗中的皮肤并发症
英文原题：Dermatologic complications in transplantation and cellular therapy for acute leukemia.
查看英文原题
Dermatologic complications in transplantation and cellular therapy for acute leukemia.
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中文摘要
过继性细胞免疫治疗，主要是造血干细胞移植和 CAR-T 细胞治疗，已经彻底改变了急性白血病患者的治疗。近年来，这些治疗的适应证和纳入标准有所扩大。虽然这些治疗与疾病缓解和 OS 的显著改善相关，但患者可能会因相关的化疗预处理、植入、细胞因子风暴、支持性药物以及移植后维持靶向治疗而出现不良事件。支持性肿瘤皮肤病学是一个不断发展的专业领域，用于管理抗癌治疗引起的皮肤毒性。在这篇综述中，我们总结了接受细胞治疗患者中常见皮肤不良事件的诊断和管理，包括药疹、移植物抗宿主病、肿瘤性和副肿瘤性并发症。
展开英文摘要原文
Adoptive cellular immunotherapy, mainly hematopoietic stem cell transplant and CAR-T cell therapy have revolutionized treatment of patients with acute leukemia. Indications and inclusion criteria for these treatments have expanded in recent years. While these therapies are associated with significant improvements in disease response and overall survival, patients may experience adverse events from associated chemotherapy conditioning, engraftment, cytokine storm, supportive medications, and post-transplant maintenance targeted therapies.
Supportive oncodermatology is a growing specialty to manage cutaneous toxicities resulting from the anti-cancer therapies. In this review, we summarize diagnosis and management of the common cutaneous adverse events including drug eruptions, graft-versus-host disease, neoplastic and paraneoplastic complications in patients undergoing cellular therapies.
论文信息
- 作者
- Babakoohi S、Gu SL、Ehsan H、Markova A
- 第一作者单位
- Levine Cancer Institute, Atrium Health Wake Forest Baptist, Charlotte, NC, USA. Electronic address: Shahab.Babakoohi@atriumhealth.org.United States
- 通讯作者单位
- Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA. Electronic address: Markovaa@mskcc.org.United States
- 文献类型
- 综述 · 美国 NIH 资助研究
- 期刊
- Best practice & research. Clinical haematology2023 Jun
- 原文标识
- PubMed 37353285 · DOI 10.1016/j.beha.2023.101464
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