帕博利珠单抗联合二甲双胍治疗转移性头颈部癌的 II 期可行性研究
A Phase II Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer.
二甲双胍联合帕博利珠单抗耐受性良好，仅出现轻度胃肠道不良事件，并展现出有前景的活性，值得在随机试验中进一步研究。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
HPV16 状态可能与下咽癌中 TIL（肿瘤浸润淋巴细胞）增加相关
英文原题：HPV16 status might correlate to increasing tumor-infiltrating lymphocytes in hypopharyngeal cancer.
查看英文原题
HPV16 status might correlate to increasing tumor-infiltrating lymphocytes in hypopharyngeal cancer.
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研究概要
HPV16 感染与肿瘤免疫浸润细胞（TILs）显著相关。
研究思路结论见上方概要
背景
人乳头瘤病毒（HPV）在头颈部鳞状细胞癌（HNSCC）患者数量不断增加中起着主要的病因学作用。
目的
本研究旨在探讨HPV感染与下咽鳞状细胞癌（HPSCC）患者预后之间的关系。
方法
我们回顾性分析了2015年至2018年连续诊断为HPSCC的108例患者。采用实时荧光定量PCR和P16免疫组化检测下咽癌患者组织中的HPV感染。通过免疫组化计数获得肿瘤实质中CD8、CD4和Foxp3细胞的数量。最后，根据患者的临床病理变量和预后进行分析。
结果
在108例HPSCC患者中，qPCR检测出18例，其中16种亚型占多数（77.8%）。Kaplan-Meier分析显示，HPV16+、较高的CD8+、较高的CD4+和较高的FoxP3+ TIL浸润与更优的三年无病生存期（DFS）、癌症特异性生存期（CSS）和总生存期（OS）密切相关。单因素分析显示，HPV和CD4+ TIL对预后具有较高的预测价值。
展开英文摘要原文
BACKGROUND
Human papillomavirus (HPV) plays a major etiological role in the increasing number of patients with head and neck squamous cell carcinoma (HNSCC).
OBJECTIVES
This study aimed at exploring the relationship between HPV infection and prognosis in patients with hypopharyngeal carcinoma (HPSCC).
METHODS
We retrospectively analyzed 108 consecutive patients diagnosed with HPSCC from 2015 to 2018. Real-time fluorescent quantitative PCR and P16 immunohistochemistry were used to detect HPV infection in tissues of patients with hypopharyngeal carcinoma. The numbers of CD8, CD4 and Foxp3 cells in tumor parenchyma were obtained by immunohistochemical counting. Finally, the analysis was performed according to the clinicopathological variables and prognosis of the patients.
RESULTS
Among 108 patients with HPSCC, 18 cases were detected by qPCR, and 16 subtypes accounted for the majority (77.8%). Kaplan-Meier analysis showed that HPV16+, higher CD8+, higher CD4+ and higher FoxP3+ TIL infiltration was strongly associated with superior three-year disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS). Univariate analysis showed that HPV and CD4+ TIL had higher predictive value for prognosis.
CONCLUSIONS
HPV16 infection is significantly related to tumor immune infiltrating cells (TILs).
论文信息
- 作者
- Ji M、Lin L、Huang Q、Hu C、Zhang M
- 单位
- Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.China
- 期刊
- Acta oto-laryngologica2023 May-Jun
- 原文标识
- PubMed 37335232 · DOI 10.1080/00016489.2023.2221288