CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
双特异性抗体时代 CAR-T 细胞治疗的作用
英文原题：The Role of Chimeric Antigen Receptor T-Cell Therapy in the Era of Bispecific Antibodies.
查看英文原题
The Role of Chimeric Antigen Receptor T-Cell Therapy in the Era of Bispecific Antibodies.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法和双特异性抗体是一类T细胞衔接免疫疗法，已在血液癌症患者中展现出相当大的前景。与传统癌症治疗相比，T细胞衔接疗法利用宿主免疫系统的力量来攻击表达目标抗原的恶性细胞。尽管这些疗法正在改变血液癌症的自然病程，但多种产品的可用性给治疗选择带来了不确定性。在这篇综述中，我们讨论CAR-T 细胞疗法在双特异性抗体新兴时代中的作用，特别关注多发性骨髓瘤。
展开英文摘要原文
Chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies are a class of T-cell engaging immunotherapies that have demonstrated considerable promise for patients with blood cancers. In comparison with traditional cancer therapeutics, T-cell engaging therapies harness the power of the host immune system to attack malignant cells expressing a target antigen of interest.
Although these therapies are altering the natural history of blood cancers, the availability of several products has created uncertainty regarding treatment selection. In this review, we discuss the role of CAR T-cell therapy in the emerging era of bispecific antibodies with a particular focus on multiple myeloma.
论文信息
- 作者
- Nath K、Mailankody S、Usmani SZ
- 第一作者单位
- Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.United States
- 通讯作者单位
- Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA; Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: usmanis@mskcc.org.United States
- 文献类型
- 综述 · 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- Hematology/oncology clinics of North America2023 Dec
- 原文标识
- PubMed 37330347 · DOI 10.1016/j.hoc.2023.05.011
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