RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞为癌症免疫治疗提供了新的方向
英文原题：NK cells direct the perspective approaches to cancer immunotherapy.
查看英文原题
NK cells direct the perspective approaches to cancer immunotherapy.
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中文摘要
自然杀伤（NK）细胞是先天免疫细胞，具有通过多种机制杀伤癌细胞的细胞毒性潜力，可应用于癌症治疗。尽管其抗肿瘤活性强大，但尤其是对实体瘤的抗肿瘤活性受到肿瘤浸润不足、抑制性肿瘤微环境、癌症相关基质细胞和支持肿瘤的免疫细胞的损害。因此，通过前瞻性策略操控或重编程这些障碍，可能改善当前临床中的免疫治疗，或引入新的基于NK的免疫治疗。基于NK的免疫治疗可以作为单一疗法开发，也可以与其他治疗方案如溶瘤病毒治疗和免疫检查点阻断联合使用，如本综述所述。
展开英文摘要原文
Natural killer (NK) cells are innate immune cells with cytotoxic potentials to kill cancerous cells in several mechanisms, which could be implied for cancer therapy. While potent, their antitumor activities specially for solid tumors impaired by inadequate tumor infiltration, suppressive tumor microenvironment, cancer-associated stroma cells, and tumor-supportive immune cells.
Therefore, manipulating or reprogramming these barriers by prospective strategies might improve current immunotherapies in the clinic or introduce novel NK-based immunotherapies. NK-based immunotherapy could be developed in monotherapy or in combination with other therapeutic regimens such as oncolytic virus therapy and immune checkpoint blockade, as presented in this review.
论文信息
- 作者
- Jalil AT、Abdulhadi MA、Al-Marzook FA、Hizam MM、Abdulameer SJ、Al-Azzawi AKJ、Zabibah RS、Fadhil AA
- 单位
- Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hilla, Babylon, Iraq. abedalazeem799@gmail.com.United States
- 文献类型
- 综述
- 期刊
- Medical oncology (Northwood, London, England)2023 Jun 15
- 原文标识
- PubMed 37318610 · DOI 10.1007/s12032-023-02066-x