间皮素作为癌症免疫治疗的生物标志物和治疗靶点
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer.
癌症仍是一个关键的全球健康问题，原因在于发现晚、耐药和高死亡率。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胃癌间质 TIL（肿瘤浸润淋巴细胞）浸润与雷帕霉素机制性靶点信号的相关性
英文原题：Infiltration of Gastric Cancer Stroma by Tumor-Infiltrating Lymphocytes Correlates with Mechanistic Target of Rapamycin Signaling.
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Infiltration of Gastric Cancer Stroma by Tumor-Infiltrating Lymphocytes Correlates with Mechanistic Target of Rapamycin Signaling.
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研究概要
mTOR 可能抑制 GC 中 TIL 的浸润。H&E 染色是评估 GC 患者免疫状态的有效工具。H&E 染色可在临床实践中用于监测 GC 的治疗反应。
研究思路结论见上方概要
背景
我们研究了通过苏木精和伊红（H&E）染色评估的胃癌（GC）中TIL（肿瘤浸润淋巴细胞）（TILs）的浸润是否可作为预后标志物。我们还探讨了TILs与雷帕霉素机制靶点（mTOR）之间的关系，以及它如何调控GC中的免疫效应应答。
方法
共纳入183例有TIL数据的患者。使用H&E染色评估TIL浸润。我们还进行了免疫组化以确定mTOR表达。
结果
TIL阳性浸润定义为TILs 20%。阳性病例72例（39.3%），阴性病例111例（60.7%）。TILs阳性与无淋巴结转移（p = 0.037）和p-mTOR阴性表达（p = 0.040）均显著相关。TIL浸润与显著更好的总生存期（p = 0.046）和无病生存期（p = 0.020）相关。
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METHODS
A total of 183 patients with available data on TIL were included. TIL infiltration was evaluated using H&E staining. We also conducted immunohistochemistry to determine mTOR expression.
RESULTS
Positive TIL infiltration was defined as TILs 20%. There were 72 (39.3%) and 111 (60.7%) positive and negative cases, respectively. TILs positivity significantly correlated with both absence of lymph node metastasis (p = 0.037) and negative p-mTOR expression (p = 0.040). TIL infiltration correlated with a significantly better overall (p = 0.046) and disease-free (p = 0.020) survival.
CONCLUSION
mTOR possibly suppresses TIL infiltration in GC. H&E staining is an effective tool for evaluating the immune status of GC patients. H&E staining may be used in clinical practice to monitor treatment response in GC.
论文信息
- 作者
- Nakazawa N、Sohda M、Katayama A、Ide M、Shimoda Y、Tateno K、Watanabe T、Sano A
- 单位
- Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan.Japan
- 期刊
- Oncology2023
- 原文标识
- PubMed 37315539 · DOI 10.1159/000531475