CRO 感染和预防性使用抗 MRSA 药物影响 CAR-T 输注后血液系统恶性肿瘤患者的预后

Carbapenem-resistant organisms (CRO) are a high priority issue because there are limited medications available to treat CRO infections, and these pathogens replicate rapidly in immunosuppressed patients, including those with hematological malignancy. Risk factors and prognosis of CRO infections after chimeric antigen receptor-modified T cells (CAR-T) therapy are unclear.

This study was conducted to analyse the risk factors for CRO infection in patients with hematological malignancies following CAR-T therapy, and prognosis 1 year after CAR-T infusion. Patients who were diagnosed with hematological malignancies and treated with CAR-T therapy between June 2018 and December 2020 at our center were included. The case group consisted of 35 patients who developed CRO infections within 1 year of CAR-T infusion, and the control group comprised 280 patients who did not develop CRO infections. Shockingly, therapy failure occurred in 62. 82% of CRO patients vs. 13.

21% of the control group (P=0. 000). Patients with CRO colonization (odds ratio [OR]=15. 48, confidence interval [CI] (6. 43-37. 25), P=0. 000) and hypoproteinemia (OR=2. 84, CI (1. 20-6. 73), P=0. 018) were susceptible to CRO infections. CRO infections (hazard ratio [HR]=4. 40, CI (2. 32-8. 37), P=0.

000), prophylaxis with combination regimens containing methicillin-resistant Staphylococcus aureus (MRSA)-active agents (HR=5. 42, CI (2. 65-11. 11), P=0. 000), and bacterial infections occurring within 30 days of CAR-T infusion (HR=1. 97, CI (1. 08-3. 59), P=0. 028) were risk factors for poor outcomes within 1 year.

This study shows that prophylaxis of CRO infection should be a top priority in CAR-T therapy, the serum albumin level of patients should be dynamically monitored and interventions put in place if necessary, and caution is required in prophylaxis with anti-MRSA activity agents.