CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤微环境胆固醇图谱为改进 CAR-T 疗法提供路径
英文原题：Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy.
查看英文原题
Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
胆固醇对于细胞毒性T细胞清除癌细胞的能力至关重要。在本期Cancer Cell中，Yan等人揭示了肿瘤内胆固醇缺乏如何通过抑制mTORC1信号传导导致T细胞耗竭。此外，他们证明通过阻断肝X受体（LXR）提高嵌合抗原受体（CAR）-T细胞中的胆固醇水平可改善抗肿瘤功能。
展开英文摘要原文
Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling.
Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.
论文信息
- 作者
- Chaves-Filho AB、Schulze A
- 第一作者单位
- Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo 05508000, Brazil.Germany
- 通讯作者单位
- Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address: almut.schulze@dkfz-heidelberg.de.Germany
- 文献类型
- 非美国政府资助研究 · 评论
- 期刊
- Cancer cell2023 Jul 10
- 原文标识
- PubMed 37244258 · DOI 10.1016/j.ccell.2023.05.013