RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞在肿瘤转移中的作用及基于 NK 细胞的免疫治疗
英文原题：The Function of NK Cells in Tumor Metastasis and NK Cell-Based Immunotherapy.
查看英文原题
The Function of NK Cells in Tumor Metastasis and NK Cell-Based Immunotherapy.
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中文摘要
转移性肿瘤是癌症患者死亡的主要原因，治疗转移仍是当前癌症研究的首要目标。尽管免疫系统可预防并杀伤肿瘤细胞，但数十年来，人们低估了免疫系统在转移性癌症中的作用，因为肿瘤能够发展复杂信号通路来抑制免疫反应，从而逃避免疫识别和清除。研究表明，基于 NK 细胞的疗法具有多项优势，是对抗转移性癌症的有前景方法。本文回顾免疫系统在肿瘤进展中的作用，重点讨论 NK 细胞抗转移能力、转移性肿瘤如何逃避 NK 细胞攻击，以及近期有效抗转移免疫疗法的发展。
展开英文摘要原文
Metastatic tumors cause the most deaths in cancer patients. Treating metastasis remains the primary goal of current cancer research. Although the immune system prevents and kills the tumor cells, the function of the immune system in metastatic cancer has been unappreciated for decades because tumors are able to develop complex signaling pathways to suppress immune responses, leading them to escape detection and elimination. Studies showed NK cell-based therapies have many advantages and promise for fighting metastatic cancers.
We here review the function of the immune system in tumor progression, specifically focusing on the ability of NK cells in antimetastasis, how metastatic tumors escape the NK cell attack, as well as the recent development of effective antimetastatic immunotherapies.
论文信息
- 作者
- Yu Y
- 单位
- Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.United States
- 文献类型
- 综述
- 期刊
- Cancers2023 Apr 16
- 原文标识
- PubMed 37190251 · DOI 10.3390/cancers15082323
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