RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞及其在临床病理学和肿瘤过程中的免疫反应多样化意义
英文原题：Natural Killer Cells and Their Implications in Immune Response Diversification in Clinical Pathology and Neoplastic Processes.
查看英文原题
Natural Killer Cells and Their Implications in Immune Response Diversification in Clinical Pathology and Neoplastic Processes.
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中文摘要
大量研究探讨了人类免疫系统生物标志物在多种实体瘤和血液肿瘤中与易感性、预后、治疗及预测因素相关的功能[...]。
展开英文摘要原文
Numerous studies have examined the function of human immune system biomarkers regarding susceptibility, and prognostic, therapeutic, and predictive factors, in various solid and liquid tumors [...].
论文信息
- 作者
- Legaz I、Muro M
- 第一作者单位
- Department of Legal and Forensic Medicine, Biomedical Research Institute of Murcia (IMIB), Regional Campus of International Excellence "Campus Mare Nostrum", Faculty of Medicine, University of Murcia (UMU), 30100 Murcia, Spain.Spain
- 通讯作者单位
- Immunology Service, University Clinical Hospital "Virgen de la Arrixaca"-IMIB, 30120 Murcia, Spain.Spain
- 文献类型
- 社论
- 期刊
- International journal of molecular sciences2023 Apr 24
- 原文标识
- PubMed 37175450 · DOI 10.3390/ijms24097743
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