CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
一例接受 CAR-T 细胞免疫治疗（I 期临床试验）的前列腺癌患者神经精神不良事件的管理：病例报告
英文原题：Management of neuropsychiatric adverse events in a prostate cancer patient undergoing chimeric antigen receptor T-cell immunotherapy (a phase I clinical trial): A case report.
查看英文原题
Management of neuropsychiatric adverse events in a prostate cancer patient undergoing chimeric antigen receptor T-cell immunotherapy (a phase I clinical trial): A case report.
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中文摘要
既往临床试验显示，CAR-T 免疫疗法对恶性实体瘤患者有初步疗效。然而治疗过程中可能出现焦虑等神经精神不良事件和认知功能障碍，从而降低患者依从性并威胁安全。护理人员能够及时识别并处理这些并发症，促进早期诊断和治疗，改善临床及患者结局；还可通过提供心理支持帮助患者坚持治疗。
展开英文摘要原文
In previous clinical trials, chimeric antigen receptor T-cell immunotherapy has shown preliminary efficacy in patients with malignant solid tumors.
However, the occurrence of adverse events, particularly neuropsychiatric adverse events (eg, anxiety) and cognitive dysfunction, during the course of treatment may reduce patient compliance and pose a threat to their safety. Nurses are in a unique position to promptly identify and manage such complications, thereby facilitating early diagnosis and treatment, as well as improving clinical and patient outcomes.
Moreover, nurses can promote compliance through the provision of psychological support to patients.
论文信息
- 作者
- Tang R、Wang Q、Han J、Shi M
- 第一作者单位
- School of Nursing, Xuzhou Medical University, Xuzhou, China.China
- 通讯作者单位
- National and Local Joint Engineering Laboratory of Tumor Biotherapy, The First Clinical College of Xuzhou Medical University, Xuzhou, China.China
- 文献类型
- 病例报告
- 期刊
- Asia-Pacific journal of oncology nursing2023 Apr
- 原文标识
- PubMed 37025985 · DOI 10.1016/j.apjon.2023.100211
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →