通过靶向肿瘤相关巨噬细胞的嵌合受体工程化溶瘤病毒重振内源性抗肿瘤免疫
Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Immunotherapy: A new target for cancer cure (Review).
Immunotherapy: A new target for cancer cure (Review).
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
癌症是全球死亡的主要原因,全球范围内癌症呈流行态势。免疫治疗已成为一种有前景的抗癌疗法。特别是溶瘤病毒通过病毒自我复制和抗肿瘤免疫反应破坏癌细胞而不破坏正常组织,显示出癌症治疗的潜力。本综述讨论了免疫系统在肿瘤治疗中的作用。从主动免疫和被动免疫治疗方面简要介绍了治疗肿瘤的策略,并重点介绍了树突状细胞疫苗和溶瘤病毒,以及血型A抗原在实体瘤治疗中的应用。
Cancer is the leading cause of death globally and there is a worldwide cancer epidemic. Immunotherapy has emerged as a promising anticancer therapy. In particular, oncolytic viruses destroy cancer cells without destroying normal tissue via viral self‑replication and anti‑tumor immune responses, showing potential for cancer therapy.
The present review discusses the role of the immune system in the treatment of tumor. The strategies for treating tumors are briefly introduced from aspects of active immunization and passive immunotherapy and the dendritic cell vaccines and oncolytic viruses are highlighted, as well as use of blood group A antigen in the treatment of solid tumors.
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