CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
病例报告：一例持续性低丙种球蛋白血症儿童 CAR-T 细胞接受者的 SARS-CoV-2 临床过程与治疗
英文原题：Case report: Clinical course and treatment of SARS-CoV-2 in a pediatric CAR-T cell recipient with persistent hypogammaglobulinemia.
查看英文原题
Case report: Clinical course and treatment of SARS-CoV-2 in a pediatric CAR-T cell recipient with persistent hypogammaglobulinemia.
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中文摘要
本报告描述一名儿童患者：其 4 年前因难治性 B 细胞急性淋巴细胞白血病（B-ALL）接受嵌合抗原受体（CAR）T 细胞治疗，随后发生低丙种球蛋白血症，目前每周接受皮下免疫球蛋白治疗。患者在确诊 COVID-19 感染 3 周后出现持续发热、干咳和脚趾刺痛。初次鼻咽部 SARS-CoV-2 PCR 检测为阴性，因此开展了针对其他感染的广泛检查。最终通过支气管肺泡灌洗液（BAL）SARS-CoV-2 PCR 阳性，确诊持续性下呼吸道 COVID-19 感染。患者接受抗病毒药物 remdesivir 联合 casirivimab/imdevimab（联合单克隆抗体）治疗后，发热、呼吸道症状和神经系统症状立即改善。
展开英文摘要原文
This report describes a pediatric patient who underwent chimeric antigen receptor (CAR) T-cell therapy for refractory B-cell acute lymphoblastic leukemia (B-ALL) four years prior, with resultant hypogammaglobulinemia for which he was receiving weekly subcutaneous immune globulin. He presented with persistent fever, dry cough, and a tingling sensation in his toes following a confirmed COVID-19 infection 3 weeks prior.
His initial nasopharyngeal SARS-CoV-2 PCR was negative, leading to an extensive workup for other infections. He was ultimately diagnosed with persistent lower respiratory tract COVID-19 infection based on positive SARS-CoV-2 PCR from bronchoalveolar lavage (BAL) sampling. He was treated with a combination of remdesivir (antiviral) and casirivimab/imdevimab (combination monoclonal antibodies) with immediate improvement in fever, respiratory symptoms, and neurologic symptoms.
论文信息
- 作者
- Sanders H、Callas C、St Amant H、Chung J、Dimitriades VR、Nakra NA
- 第一作者单位
- Department of Pediatrics, University of California Davis Medical School, Sacramento, CA, United States.United States
- 通讯作者单位
- Division of Pediatric Infectious Diseases, Department of Pediatrics, University of California Davis Medical School, Sacramento, CA, United States.United States
- 文献类型
- 病例报告
- 期刊
- Frontiers in pediatrics2023
- 原文标识
- PubMed 36969291 · DOI 10.3389/fped.2023.1076686
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →