CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于人类癌症转化研究的实验小鼠模型
英文原题：Experimental mouse models for translational human cancer research.
查看英文原题
Experimental mouse models for translational human cancer research.
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中文摘要
动物模型对于研究肿瘤发生、发展及恶性转化的机制，以及评估潜在治疗方法具有重要价值。本文综述目前用于肿瘤研究的动物模型，重点介绍小鼠和大鼠模型，包括自发性肿瘤模型、化学或其他方式诱导的模型、转基因模型，以及可移植肿瘤模型。不同模型各有特点，可用于回答不同类型的生物学和治疗问题。合理选择并理解模型的适用范围，有助于更准确地研究肿瘤生物学并推动治疗策略的临床转化。
展开英文摘要原文
The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the malignant initiation and progression of cancer remains a controversial issue, and further research is urgently required.
The experimental animal model not only has great advantages in simulating the occurrence, development, and malignant transformation mechanisms of tumors, but also can be used to evaluate the therapeutic effects of a diverse array of clinical interventions, gradually becoming an indispensable method for cancer research.
In this paper, we have reviewed recent research progress in relation to mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, to help guide the future study of malignant mechanisms and tumor prevention.
论文信息
- 作者
- Zhou Y、Xia J、Xu S、She T、Zhang Y、Sun Y、Wen M、Jiang T
- 单位
- Department of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medicel University, Xi'an, China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2023
- 原文标识
- PubMed 36969176 · DOI 10.3389/fimmu.2023.1095388
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