CELL INTELLIGENCE · 肿瘤细胞治疗研究

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肿瘤靶向治疗的分子基础与临床应用

英文原题：Molecular basis and clinical application of targeted therapy in oncology.

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Molecular basis and clinical application of targeted therapy in oncology.

PubMed 2023/02/28（内容时间） Med J Armed Forces India

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技术：CAR-T地区：亚太其他
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中文摘要

精准肿瘤学旨在针对肿瘤独特的分子特征制定个体化治疗方案。基因组学、蛋白质组学和转录组学等组学技术，以及下一代测序（NGS）和循环肿瘤细胞、循环肿瘤DNA等液体活检方法，为识别肿瘤分子特征提供了重要工具。治疗策略包括靶向单克隆抗体、细胞内靶点的小分子药物，以及免疫肿瘤学疗法，例如免疫检查点抑制剂和CAR-T 细胞疗法。精准治疗也带来特定不良反应，需结合患者和肿瘤特征加以管理。本文综述精准肿瘤学的分子基础、诊断方法及其在肿瘤临床实践中的应用，并讨论其当前进展与挑战。

展开英文摘要原文

Targeted therapy and precision oncology aim to improve efficacy and minimize side effects by targeting specific molecules involved in cancer growth and spread. With the advancements in genomics, proteomics, and transcriptomics with the accessible modalities such as next-generation sequencing, circulating tumor cells, and tumor Deoxyribonucleic Acid (DNA), more number of patients are being offered the targeted therapy in form of monoclonal antibodies and various intracellular targets, specific for their tumor.

The harnessing of host immunity against the cancer cells by utilizing immune-oncology agents and chimeric antigen receptor T-cell therapy has further revolutionized the management of various cancers. These agents, however, have the challenge of managing the adverse effects that are peculiar to the class of drugs and very different from the conventional chemotherapy. This review article discusses the molecular basis, diagnostics, and use of targeted therapy in oncology.

论文信息

作者
Tilak TVSVGK、Patel A、Kapoor A
第一作者单位
Professor & Head, Department of Geriatric Medicine, Armed Forces Medical College, Pune, India.India
通讯作者单位
Consultant & Head, MDTC, Army Hospital (R&R), Delhi Cantt, India.India
文献类型
综述
期刊
Medical journal, Armed Forces India2023 Mar-Apr
原文标识
PubMed 36969115　·　DOI 10.1016/j.mjafi.2023.02.001

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