CELL INTELLIGENCE · 肿瘤细胞治疗研究

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通过干细胞工程推进基于细胞的肿瘤免疫治疗

英文原题：Advancing cell-based cancer immunotherapy through stem cell engineering.

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Advancing cell-based cancer immunotherapy through stem cell engineering.

PubMed 2023/03/21（内容时间） Cell Stem Cell Q1 · IF 23.3（JCR 2025）

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技术：CAR-T技术：基因编辑血液系统恶性肿瘤实体瘤地区：美国
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中文摘要

细胞疗法，特别是CAR-T 细胞疗法的进步，已改变血液系统恶性肿瘤的治疗。尽管自体CAR-T 疗法是该领域的重要进步，但其仍受高成本、制备挑战及治疗实体瘤疗效有限所阻碍。随着基因编辑和培养技术不断进步，工程化干细胞及其在细胞治疗中的应用有望解决其中部分挑战。本文综述以干细胞为基础的免疫治疗方法、干细胞来源、基因工程和制备策略、治疗平台及临床试验，并讨论该领域面临的挑战和未来发展方向。

展开英文摘要原文

Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the treatment of hematological malignancies. Although an important step forward for the field, autologous CAR-T therapies are hindered by high costs, manufacturing challenges, and limited efficacy against solid tumors. With ongoing progress in gene editing and culture techniques, engineered stem cells and their application in cell therapy are poised to address some of these challenges.

Here, we review stem cell-based immunotherapy approaches, stem cell sources, gene engineering and manufacturing strategies, therapeutic platforms, and clinical trials, as well as challenges and future directions for the field.

论文信息

作者
Li YR、Dunn ZS、Yu Y、Li M、Wang P、Yang L
第一作者单位
Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.United States
通讯作者单位
Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: liliyang@ucla.edu.United States
文献类型
综述 · 美国 NIH 资助研究 · 非美国政府资助研究
期刊
Cell stem cell2023 May 4
原文标识
PubMed 36948187　·　DOI 10.1016/j.stem.2023.02.009

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