RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
姜黄素通过促进抗肿瘤免疫反应增强多西他赛在头颈部鳞状细胞癌中的疗效
英文原题：Curcumin Enhances the Efficacy of Docetaxel by Promoting Anti-Tumor Immune Response in Head and Neck Squamous Cell Carcinoma.
查看英文原题
Curcumin Enhances the Efficacy of Docetaxel by Promoting Anti-Tumor Immune Response in Head and Neck Squamous Cell Carcinoma.
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中文摘要
本研究评估了姜黄素与多西他赛（DTX）联合治疗头颈部鳞状细胞癌（HNSCC）的可行性。动物实验表明，DTX在改善免疫抑制微环境方面存在一定局限性。姜黄素治疗克服了这种抑制作用并减少了肿瘤进展。姜黄素与DTX协同作用显示，通过下调MDSCs、M2巨噬细胞以及上调CD8+ T细胞、NK细胞、M1巨噬细胞，肿瘤负荷的减少显著大于任一单独治疗。同时，肿瘤中CXCL1的分泌减少。相反，干扰素-γ和肿瘤坏死因子-α的分泌增加。我们的研究为HNSCC提供了一种有前景的治疗策略。
展开英文摘要原文
This study evaluated the feasibility of curcumin and docetaxel (DTX) combination therapy for head and neck squamous cell carcinoma (HNSCC). Animal assay demonstrated DTX has certain limitations in improving immunosuppressive microenvironment. Treatment with curcumin overcame this inhibition and reduced tumor progression.
Curcumin synergized DTX showed significantly greater reduction in tumor burden than either treatment alone via down-regulation of MDSCs, M2 macrophages and up-regulation of CD8 + T cells, NK cells, M1 macrophages. Meanwhile, the secretion of CXCL1 was decreased in tumor. Conversely, the secretion of interferon-γ and tumor necrosis factor-α were increased.
Our study provided a promising therapeutic strategy for HNSCC.
论文信息
- 作者
- Sun L、Yao X、Liu J、Zhang Y、Hu J
- 单位
- The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.China
- 期刊
- Cancer investigation2023 May
- 原文标识
- PubMed 36946609 · DOI 10.1080/07357907.2023.2194420