RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Recent advances in the liposomal nanovesicles based immunotherapy in the treatment of cancer: A review.
Recent advances in the liposomal nanovesicles based immunotherapy in the treatment of cancer: A review.
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免疫疗法与化疗、靶向递送、放疗和手术一样,已成为最常见的癌症治疗方法之一。癌症免疫学的目标是利用人体免疫系统对抗肿瘤,并产生强大的抗肿瘤免疫反应。在过去几年中,免疫检查点抑制剂和嵌合抗原受体修饰的T细胞在癌症免疫治疗方面取得了实质性进展。通过增强细胞类型特异性递送和免疫反应,脂质体等纳米载体能够增强更大的免疫反应。由于脂质体有助于解决多种癌症免疫治疗中可能出现的若干问题,抗肿瘤治疗药物的疗效正在显著提高。由于脂质体可以同时装载亲水性和疏水性药物,并保护装载在核心内的免疫治疗药物,因此它们比其他纳米递送系统具有显著优势。利用脂质体将免疫疗法准确、及时地递送至特定的靶向肿瘤,同时对健康细胞造成很少或没有损伤,可最大限度地提高免疫疗法疗效。脂质体也是将药物与化疗、放疗和光疗等其他疗法同时递送的合适载体。脂质体纳米颗粒将被引入并用作具有高精度的客观免疫疗法递送系统,使其成为一种可行的癌症治疗方法。本综述重点关注树突状细胞、T细胞、肿瘤和NK 细胞以及巨噬细胞;概述了肿瘤学中多种形式的免疫疗法,以及用于癌症免疫治疗的脂质体纳米囊泡的前沿进展。
Immunotherapy, along with chemotherapy, targeted delivery, radiation and surgery has become one of the most common cancer treatments. The aim of cancer immunology is to use the bodys immune system to combat tumors and develop a robust antitumor immune response. In the last few years, immune checkpoint inhibitors and chimeric antigen receptor-modified T cells have made substantial advancements in cancer immunotherapy. By boosting cell type-specific delivery and immunological responses, nanocarriers like liposomes have the ability to enhance greater immune responses. The efficacy of anti-tumor therapeutics is being significantly improved as liposomes can assist in resolving a number of issues that can arise from a variety of cancer immunotherapies.
Since, liposomes can be loaded with both hydrophilic and hydrophobic drugs and protect the immunotherapeutic agents loaded inside the core, they offer significant advantages over other nano delivery systems. The use of liposomes for accurate and timely delivery of immunotherapies to particular targeted neoplasms, with little or no injury to healthy cells, maximizes immunotherapy efficacy. Liposomes are also suitable vehicles for delivering medications simultaneously with other therapies such as chemotherapy, radiation, and phototherapy.
Liposomal nanoparticles will be introduced and used as an objective immunotherapy delivery system for great precision, making them a viable cancer treatment approach. With an emphasis on dendritic cells, T cells, tumor and natural killer cells, and macrophages; outline of many forms of immune-therapies in oncology and cutting-edge advances in liposomal nanovesicles for cancer immunotherapy are covered in this review.
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