免疫检查点阻断通过扩增效应 CD8⁺ T 细胞克隆增强淋巴细胞清除性化疗诱导的抗肿瘤免疫
Immune Checkpoint Blockade Augments Lymphodepleting Chemotherapy-Induced Antitumor Immunity by Expanding Effector CD8+ T-cell Clones.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
TCR 多样性是免疫治疗成功的基础
英文原题：TCR Diversity Underpins Immunotherapy Success.
查看英文原题
TCR Diversity Underpins Immunotherapy Success.
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中文摘要
针对少数癌症特异性靶点的多样化T细胞库是转移性黑色素瘤患者免疫检查点阻断成功的关键，这一发现可能影响新抗原特异性疫苗和过继细胞疗法的设计。
展开英文摘要原文
A diverse repertoire of T cells directed against a small number of cancer-specific targets is key to the success of immune checkpoint blockade in patients with metastatic melanoma, a finding that could shape the design of neoantigen-specific vaccines and adoptive cell therapies.
论文信息
- 期刊
- Cancer discovery2023 May 4
- 原文标识
- PubMed 36939266 · DOI 10.1158/2159-8290.CD-NB2023-0019