PROTAC 工程化蛋白/DNA 纳米抗原是癌症免疫治疗中树突状细胞疫苗的有效增强剂
PROTAC-Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
铜掺杂的 TiO(2) 纳米颗粒改善局部抗肿瘤免疫激活并优化树突状细胞疫苗策略
英文原题：Cu-doped TiO(2) nanoparticles improve local antitumor immune activation and optimize dendritic cell vaccine strategies.
查看英文原题
Cu-doped TiO(2) nanoparticles improve local antitumor immune activation and optimize dendritic cell vaccine strategies.
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中文摘要
纳米颗粒介导的癌症免疫治疗前景广阔，但要获得能够全面激活固有免疫和适应性免疫组分并特异性靶向肿瘤的纳米制剂，仍需更多努力。我们制备了一系列铜掺杂TiO2纳米颗粒，以调控残余TiO2纳米晶体中Cu2+离子释放的动力学和完全释放程度。通过精细调控纳米颗粒性质，获得了33% Cu掺杂TiO2的制剂，该制剂能够实现树突状细胞的短时超激活，从而促进免疫治疗。该纳米颗粒可在离体条件下高效激活树突状细胞，将其移植到荷瘤小鼠体内后，其治疗效果超过了经典刺激的树突状细胞所获得的疗效。有效但简单的纳米材料能够促进树突状癌细胞疫苗策略，为改善免疫治疗和人类健康开辟了新途径。
展开英文摘要原文
Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors.
We generated a series of copper-doped TiO 2 nanoparticles in order to tune the kinetics and full extent of Cu 2+ ion release from the remnant TiO 2 nanocrystals. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO 2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy.
The nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells. Efficacious but simple nanomaterials that can promote dendritic cancer cell vaccination strategies open up new avenues for improved immunotherapy and human health.
论文信息
- 作者
- Hesemans E、Saffarzadeh N、Maksoudian C、Izci M、Chu T、Rios Luci C、Wang Y、Naatz H
- 第一作者单位
- NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.Belgium
- 通讯作者单位
- NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. s.soenen@kuleuven.be.Belgium
- 期刊
- Journal of nanobiotechnology2023 Mar 13
- 原文标识
- PubMed 36915084 · DOI 10.1186/s12951-023-01844-z
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