CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞疗法治疗成人 B 细胞急性淋巴细胞白血病：state-of-the-(C)ART 与未来之路
英文原题：Chimeric antigen receptor T-cell therapy for adult B-cell acute lymphoblastic leukemia: state-of-the-(C)ART and the road ahead.
查看英文原题
Chimeric antigen receptor T-cell therapy for adult B-cell acute lymphoblastic leukemia: state-of-the-(C)ART and the road ahead.
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中文摘要
自体抗CD19嵌合抗原受体（CAR）T细胞疗法近期已加入治疗B细胞急性淋巴细胞白血病（B-ALL）的手段。本综述讨论促使美国食品药品监督管理局批准CAR-T 疗法用于B-ALL患者的临床试验。我们评估CAR-T 时代异基因造血干细胞移植的作用变化，并讨论从ALL CAR-T 细胞疗法早期实践中获得的经验。此外，本文介绍CAR技术的未来创新，包括联合及替代靶点策略，以及现货型异基因CAR-T 细胞方案。最后，我们展望CAR-T 细胞在不久的将来可能如何用于成人B-ALL患者的管理。
展开英文摘要原文
Autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has recently been added to the armamentarium in the battle against B-cell acute lymphoblastic leukemia (B-ALL). In this review, we discuss the trials that led to US Food and Drug Administration approval of CAR T-cell therapies in patients with B-ALL.
We evaluate the evolving role of allogeneic hematopoietic stem cell transplant in the CAR T-cell era and discuss lessons learned from the first steps with CAR T-cell therapy in ALL. Upcoming innovations in CAR technology, including combined and alternative targets and off-the-shelf allogeneic CAR T-cell strategies are presented.
Finally, we envision the role that CAR T cells could take in the management of adult patients with B-ALL in the near future.
论文信息
- 作者
- Pasvolsky O、Kebriaei P、Shah BD、Jabbour E、Jain N
- 第一作者单位
- Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX.United States
- 通讯作者单位
- Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.United States
- 文献类型
- 综述
- 期刊
- Blood advances2023 Jul 25
- 原文标识
- PubMed 36912764 · DOI 10.1182/bloodadvances.2022009462
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