CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
不止于表面：影像学在指导晚期黑色素瘤 CAR-T 细胞治疗中作用的综述
英文原题：More than Just Skin-Deep: A Review of Imaging's Role in Guiding CAR T-Cell Therapy for Advanced Melanoma.
查看英文原题
More than Just Skin-Deep: A Review of Imaging's Role in Guiding CAR T-Cell Therapy for Advanced Melanoma.
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中文摘要
晚期黑色素瘤是最致命的癌症之一，原因在于其侵袭性强且易产生治疗耐药。手术仍是早期肿瘤的一线治疗，但通常不适用于晚期黑色素瘤。化疗预后不佳；尽管靶向治疗有所进展，癌症仍可能产生耐药。CAR-T 细胞疗法治疗血液系统癌症取得巨大成功，目前临床试验正将其用于晚期黑色素瘤。黑色素瘤仍是一种治疗困难的疾病，而影像学在监测CAR-T 细胞及治疗应答方面将发挥越来越重要的作用。我们综述晚期黑色素瘤当前影像技术，以及新型PET示踪剂和影像组学，以指导CAR-T 细胞疗法并管理潜在不良事件。
展开英文摘要原文
Advanced melanoma is one of the deadliest cancers, owing to its invasiveness and its propensity to develop resistance to therapy. Surgery remains the first-line treatment for early-stage tumors but is often not an option for advanced-stage melanoma. Chemotherapy carries a poor prognosis, and despite advances in targeted therapy, the cancer can develop resistance.
CAR T-cell therapy has demonstrated great success against hematological cancers, and clinical trials are deploying it against advanced melanoma. Though melanoma remains a challenging disease to treat, radiology will play an increasing role in monitoring both the CAR T-cells and response to therapy.
We review the current imaging techniques for advanced melanoma, as well as novel PET tracers and radiomics, in order to guide CAR T-cell therapy and manage potential adverse events.
论文信息
- 作者
- Prendergast CM、Capaccione KM、Lopci E、Das JP、Shoushtari AN、Yeh R、Amin D、Dercle L
- 第一作者单位
- Department of Radiology, Columbia University Irving Medical Center, New York, NY 10032, USA.United States
- 通讯作者单位
- Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.United States
- 文献类型
- 综述
- 期刊
- Diagnostics (Basel, Switzerland)2023 Mar 5
- 原文标识
- PubMed 36900136 · DOI 10.3390/diagnostics13050992
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