CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
免疫检查点抑制剂与嵌合抗原受体 (CAR)-T 细胞治疗：睾丸生殖细胞肿瘤的潜在治疗选择
英文原题：Immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR)-T cell therapy: Potential treatment options against Testicular Germ Cell Tumors.
查看英文原题
Immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR)-T cell therapy: Potential treatment options against Testicular Germ Cell Tumors.
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中文摘要
生殖细胞肿瘤（GCT）是一类异质性肿瘤，累及性腺，少数发生于性腺外。大多数患者预后良好，即便出现转移性疾病也往往如此；然而，约15%的患者会复发并出现铂类耐药，这是主要治疗挑战。因此，亟需开发相比铂类具有更强抗肿瘤活性且治疗相关不良事件较少的新策略。在此背景下，免疫检查点抑制剂在实体瘤中的发展及其显示出的高活性，以及嵌合抗原受体（CAR）T细胞疗法在血液系统肿瘤中取得的令人鼓舞的结果，推动了GCT领域相关研究。本文分析免疫作用参与GCT发生发展的分子机制，并报告在这些肿瘤中测试新型免疫治疗方法的研究数据。
展开英文摘要原文
Germ cell tumors (GCTs) represent a heterogeneous neoplasm family affecting gonads and rarely occurring in extragonadal areas. Most of patients have a good prognosis, often even in the presence of metastatic disease; however, in almost 15% of cases, tumor relapse and platinum resistance are the main challenges.
Thus, novel treatment strategies with both improved antineoplastic activity and minor treatment-related adverse events compared with platinum are really expected. In this context, the development and the high activity demonstrated by immune checkpoint inhibitors in solid tumors and, subsequently, the interesting results obtained from the use of chimeric antigen receptor (CAR-) T cell therapy in hematological tumors, have stimulated research in this direction also in GCTs.
In this article, we will analyze the molecular mechanisms underlying the immune action in the development of GCTs, and we will report the data from the studies that tested the new immunotherapeutic approaches in these neoplasms.
论文信息
- 作者
- Schepisi G、Gianni C、Cursano MC、Gallà V、Menna C、Casadei C、Bleve S、Lolli C
- 单位
- Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.Italy
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2023
- 原文标识
- PubMed 36860862 · DOI 10.3389/fimmu.2023.1118610
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