CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
细胞因子释放综合征与 CAR-T 细胞治疗其他副作用概述
英文原题：An Overview of Cytokine Release Syndrome and Other Side Effects of CAR-T Cell Therapy.
查看英文原题
An Overview of Cytokine Release Syndrome and Other Side Effects of CAR-T Cell Therapy.
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中文摘要
过去十年，肿瘤学快速发展，治疗手段取得巨大进步。嵌合抗原受体（CAR）T 细胞等工程化细胞疗法日益用于日常临床实践，尤其改变了血液系统恶性肿瘤治疗格局。细胞疗法的开发是科学和技术成就，但其毒性可能危及生命。随着应用范围扩大，深入理解病理生理机制有助于改善毒性管理。本文概述细胞治疗毒性及其管理。
展开英文摘要原文
Oncology has been rapidly evolving over the past decade with tremendous therapeutic development. Engineered cell therapies such as chimeric antigen receptor (CAR)-T cells are increasingly used in daily practice, and provided a paradigm change especially for hematological malignancies.
Their development is a scientific and technological achievement, but their toxicities can be life-threatening. As their utilization expands, better understanding of pathophysiology leads to better management. In this article we present a general overview of cell-therapy toxicities and their management.
论文信息
- 作者
- Genoud V、Migliorini D
- 单位
- Department of Oncology, University Hospital of Geneva, Geneva, Switzerland.Switzerland
- 期刊
- Praxis2023
- 原文标识
- PubMed 36855881 · DOI 10.1024/1661-8157/a003980