CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Immunotherapy in cervical cancer: From the view of scientometric analysis and clinical trials.
Immunotherapy in cervical cancer: From the view of scientometric analysis and clinical trials.
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对 1, 255 篇文献的科学计量学分析和对临床试验的分析均表明，近年来宫颈癌免疫治疗领域发展迅速。研究发现，大量使用各种免疫疗法（主要是疫苗治疗、过继性细胞治疗、免疫检查点阻断和抗体-药物偶联物）治疗晚期宫颈癌的临床试验目前正在进行中，或已显示出相当大的效果。以免疫疗法为中心，免疫检查点阻断已显示出巨大的疗效和潜力，特别是与化疗、靶向治疗和其他免疫疗法等其他疗法联合使用时。
宫颈癌是全球女性中第四大常见癌症，也是第四大癌症相关死亡原因。目前晚期宫颈癌患者的治疗选择有限。在迫切需要为这些患者提供一线和二线新型有效疗法的背景下，免疫治疗发展迅速并取得了一些成果。
本研究纳入了1999年至2022年Web of Science核心合集（WoSCC）中1,255篇与主题相关的文章和综述。WoS平台、Citespace和VOS viewer分别提供了出版物和引文的年度分布、研究国家和机构分析、参考文献、关键词（共现分析、突现分析和时间线视图分析）以及研究作者分析。在临床试验方面，分别从ClinicalTrials.gov和ICTRP检索到720项试验和114项试验。最终有296项试验被纳入分析。
科学计量分析显示，近年来宫颈癌免疫治疗研究发展迅速。大多数出版物来自美国，其次是中国。排名前10的共被引参考文献中有7篇属于临床试验，其中5篇发表于近五年。大量临床试验采用了特定的治疗方案，其中一些已展现出显著疗效。
Cervical cancer is the fourth most cancer and the fourth leading cause of cancer-related deaths in women worldwide. Current treatment for patients with advanced cervical cancer is limited. And in the urgent demand for novel effective therapies both as the first and the second line treatment for these patients, immunotherapy is developing fast and has made some achievements.
This study incorporated 1,255 topic-related articles and reviews from 1999 to 2022 in the Web of Science Core Collection (WoSCC). The WoS platform, Citespace, and VOS viewer provided the annual distribution of publications and citations, the analysis of researching countries and institutions, references, keywords (co-occurrence analysis, burst analysis, and timeline view analysis), and researching authors, respectively. For clinical trials, 720 trials and 114 trials from ClinicalTrials.gov and ICTRP were retrieved, respectively. And 296 trials were finally incorporated into the analysis.
The scientometric analysis showed that the study of immunotherapies in cervical cancer developed fast in recent years. Most publications were from the United States, followed by China. Seven of the top 10 co-cited references belong to clinical trials, and five of them were published in recent five years. There are lots of clinical trials us specific treatment patterns, some of which have represented excellent effects.
Both the scientometric analysis of the 1,255 publications and the analysis of clinical trials showed that the field of immunotherapies in cervical cancer developed so fast in recent years. It was found that a lot of clinical trials using various immunotherapies (mainly vaccine therapy, adoptive cell therapy, immune checkpoint blockade, and antibody-drug conjugate) for advanced cervical cancer are currently ongoing or have represented considerable effect. Centered in immunotherapies, immune checkpoint blockades have represented great efficacy and huge potential, especially combined with other therapies such as chemotherapy, targeted therapy, and other immunotherapies.
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