CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
短链脂肪酸改善体外 T 细胞与 CAR-T 细胞适应性与扩增用于肿瘤免疫治疗的潜在作用
英文原题：The potential role of short chain fatty acids improving ex vivo T and CAR-T cell fitness and expansion for cancer immunotherapies.
查看英文原题
The potential role of short chain fatty acids improving ex vivo T and CAR-T cell fitness and expansion for cancer immunotherapies.
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中文摘要
TIL（肿瘤浸润淋巴细胞）或CAR-T 细胞等过继细胞疗法，已成为重要的抗癌免疫治疗方法。T细胞免疫疗法的主要挑战之一，是如何获得最有效的T细胞表型、持久性和分化潜能，以便输注给患者。调整T细胞体外培养条件是提高和改善细胞免疫疗法效果的关键。本综述总结短链脂肪酸（一类肠道微生物群来源代谢产物）对免疫疗法中T细胞体外培养和扩增的影响。肠道微生物群与免疫系统之间存在复杂相互作用，可能影响抗肿瘤免疫疗效。事实上，肠道微生物群来源代谢产物能够在局部及全身调节免疫系统的多种生物学功能。
展开英文摘要原文
Adoptive cell therapies, like tumor-infiltrating lymphocytes or chimeric antigen receptor T cells, have become an important immunotherapeutic approach against cancer. One of the main struggles of T cell immunotherapies is how to obtain the most effective T cell phenotype, persistence, and differentiation potential to infuse into patients. Adjusting the T cell ex vivo cell culture conditions is a key factor to increase and improve the efficacy of cellular immunotherapies.
In this review, we have summarized the ex vivo impact of short chain fatty acids, a group of gut microbiota derived metabolites, on T cell culture and expansion for immunotherapies. There is a complex gut microbiota-immune system interaction that can affect antitumor immunotherapy efficacy. Indeed, gut microbiota derived metabolites can modulate different biological functions in the immune system local and systemically.
论文信息
- 作者
- González-Brito A、Uribe-Herranz M
- 单位
- Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain.Spain
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2023
- 原文标识
- PubMed 36742300 · DOI 10.3389/fimmu.2023.1083303
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