CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
BATF 重编程肿瘤免疫状态
英文原题：BATF reprograms the tumor immune status.
查看英文原题
BATF reprograms the tumor immune status.
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中文摘要
AP-1 家族成员 BATF 可维持免疫细胞功能。Zhang 等人¹和 Itahashi 等人²近期发表的两项研究考察了该蛋白在肿瘤免疫中的作用，发现耗减 CAR-T 细胞中的 BATF 可增强抗肿瘤活性，而 BATF 也参与肿瘤微环境中由调节性 T 细胞介导的免疫抑制。
展开英文摘要原文
The AP-1 family member BATF maintains immune cell function. Two recent papers by Zhang et al. 1 and Itahashi et al. 2 investigated the role of this protein in cancer immunity, finding that its depletion in CAR-T cells augments anti-tumor activity and it contributes to Treg-mediated immunosuppression in the tumor microenvironment.
论文信息
- 作者
- Fan T、Xiao C、Muhammad S、Li C、He J
- 第一作者单位
- Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.China
- 通讯作者单位
- Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address: hejie@cicams.ac.cn.China
- 文献类型
- 非美国政府资助研究 · 评论
- 期刊
- Med (New York, N.Y.)2023 Jan 13
- 原文标识
- PubMed 36640752 · DOI 10.1016/j.medj.2022.12.004