RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
LEF1 在 iNKT 细胞中创造记忆，从而增强抗肿瘤免疫
英文原题：LEF1 Creates Memories in iNKT Cells That Potentiate Antitumor Immunity.
查看英文原题
LEF1 Creates Memories in iNKT Cells That Potentiate Antitumor Immunity.
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中文摘要
恒定自然杀伤T（iNKT）细胞是先天样T细胞的一个亚群，在开发癌症免疫疗法方面具有巨大潜力，包括基于嵌合抗原受体（CAR）的方法。在本期，Ngai及其同事报道，转录因子淋巴增强结合因子1（LEF1）优化了iNKT细胞促进抗肿瘤免疫的功能特性，这提高了人们对开发基于CAR修饰iNKT细胞的稳健癌症免疫疗法的热情。参见Ngai等人的相关文章，第171页（2）。
展开英文摘要原文
Invariant natural killer T (iNKT) cells are a subset of innate-like T cells with great potential for developing cancer immunotherapies, including approaches based on chimeric antigen receptors (CAR). In this issue, Ngai and colleagues report that the transcription factor lymphoid enhancer-binding factor 1 (LEF1) optimizes functional properties of iNKT cells that promote antitumor immunity, raising enthusiasm for the development of robust cancer immunotherapies based on CAR-modified iNKT cells. See related article by Ngai et al., p. 171 (2).
论文信息
- 作者
- Van Kaer L
- 单位
- Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.United States
- 文献类型
- 评论
- 期刊
- Cancer immunology research2023 Feb 3
- 原文标识
- PubMed 36630221 · DOI 10.1158/2326-6066.CIR-22-0902