CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
T 细胞恶性肿瘤的过继细胞治疗
英文原题：Adoptive Cell Therapy for T-Cell Malignancies.
查看英文原题
Adoptive Cell Therapy for T-Cell Malignancies.
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中文摘要
T细胞恶性肿瘤通常侵袭性强、预后较差。近期，过继细胞疗法作为血液系统恶性肿瘤的一种新治疗方式显示出前景，但将其用于T细胞恶性肿瘤仍面临挑战。临床前和临床研究已探索多种克服这些障碍的方法。本文综述T细胞恶性肿瘤过继细胞疗法的最新进展，讨论不同类型过继细胞疗法的优缺点，并重点介绍基于先天免疫细胞的过继细胞疗法在T细胞恶性肿瘤中的潜在优势和现有应用。
展开英文摘要原文
T-cell malignancies are often aggressive and associated with poor prognoses. Adoptive cell therapy has recently shown promise as a new line of therapy for patients with hematological malignancies.
However, there are currently challenges in applying adoptive cell therapy to T-cell malignancies. Various approaches have been examined in preclinical and clinical studies to overcome these obstacles. This review aims to provide an overview of the recent progress on adoptive cell therapy for T-cell malignancies. The benefits and drawbacks of different types of adoptive cell therapy are discussed. The potential advantages and current applications of innate immune cell-based adoptive cell therapy for T cell malignancies are emphasized.
论文信息
- 作者
- Fang KK、Lee JB、Zhang L
- 单位
- Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.Canada
- 文献类型
- 综述
- 期刊
- Cancers2022 Dec 23
- 原文标识
- PubMed 36612092 · DOI 10.3390/cancers15010094
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