RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
聚焦 NK 细胞与 ADCC：HER2 阳性乳腺癌靶向治疗中一种有前景的免疫治疗策略
英文原题：Focusing on NK cells and ADCC: A promising immunotherapy approach in targeted therapy for HER2-positive breast cancer.
查看英文原题
Focusing on NK cells and ADCC: A promising immunotherapy approach in targeted therapy for HER2-positive breast cancer.
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中文摘要
人表皮生长因子受体2（HER2）阳性乳腺癌具有高度转移潜能。靶向HER2的单克隆抗体（mAbs），如曲妥珠单抗和帕妥珠单抗，是HER2阳性乳腺癌辅助治疗的基石。越来越多的临床前和临床证据表明，由抗体依赖性细胞介导的细胞毒性（ADCC）介导的先天免疫在mAbs对由此产生的抗肿瘤反应的临床效果中具有重要作用。在这篇综述中，我们概述了自然杀伤（NK）细胞和ADCC在HER2阳性乳腺癌靶向治疗中的作用，包括NK细胞的生物学功能以及NK细胞和ADCC在抗HER2靶向药物中的作用。然后，我们讨论了调控机制以及利用我们对NK细胞和ADCC的认识作为HER2阳性乳腺癌免疫治疗方法的最新策略。
展开英文摘要原文
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer has a high metastatic potential. Monoclonal antibodies (mAbs) that target HER2, such as trastuzumab and pertuzumab, are the cornerstone of adjuvant therapy for HER2-positive breast cancer.
A growing body of preclinical and clinical evidence points to the importance of innate immunity mediated by antibody-dependent cellular cytotoxicity (ADCC) in the clinical effect of mAbs on the resulting anti-tumor response. In this review, we provide an overview of the role of natural killer (NK) cells and ADCC in targeted therapy of HER2-positive breast cancer, including the biological functions of NK cells and the role of NK cells and ADCC in anti-HER2 targeted drugs.
We then discuss regulatory mechanisms and recent strategies to leverage our knowledge of NK cells and ADCC as an immunotherapy approach for HER2-positive breast cancer.
论文信息
- 作者
- Li F、Liu S
- 单位
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai,  China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2022
- 原文标识
- PubMed 36601109 · DOI 10.3389/fimmu.2022.1083462
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