CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
儿童脑肿瘤 CAR-T 细胞免疫治疗的进展
英文原题：Advances in CAR T cell immunotherapy for paediatric brain tumours.
查看英文原题
Advances in CAR T cell immunotherapy for paediatric brain tumours.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
脑肿瘤是儿童中最常见的实体肿瘤，也是儿童癌症相关死亡的主要原因。目前的治疗包括手术、化疗和放疗。由于需要积极治疗，许多幸存者遗留永久性严重残疾，包括身体、智力和社会方面。近年来免疫治疗的进展，包括用于治疗癌症的基因工程嵌合抗原受体（CAR）T细胞，可能为改善儿童脑肿瘤患者的预后提供新途径。在这篇综述中，我们讨论CAR-T 细胞免疫治疗的进展、正在临床和临床前开发中的主要CAR-T 细胞靶点（重点关注儿童脑肿瘤）、儿童脑肿瘤微环境，以及用于改善儿童肿瘤CAR-T 细胞治疗的策略。
展开英文摘要原文
Brain tumours are the most common solid tumour in children and the leading cause of cancer related death in children. Current treatments include surgery, chemotherapy and radiotherapy. The need for aggressive treatment means many survivors are left with permanent severe disability, physical, intellectual and social.
Recent progress in immunotherapy, including genetically engineered T cells with chimeric antigen receptors (CARs) for treating cancer, may provide new avenues to improved outcomes for patients with paediatric brain cancer. In this review we discuss advances in CAR T cell immunotherapy, the major CAR T cell targets that are in clinical and pre-clinical development with a focus on paediatric brain tumours, the paediatric brain tumour microenvironment and strategies used to improve CAR T cell therapy for paediatric tumours.
论文信息
- 作者
- Rao P、Furst L、Meyran D、Mayoh C、Neeson PJ、Terry R、Khuong-Quang DA、Mantamadiotis T
- 单位
- Translational Tumour Biology, Children's Cancer Institute, Randwick, NSW, Australia.Australia
- 文献类型
- 综述
- 期刊
- Frontiers in oncology2022
- 原文标识
- PubMed 36505819 · DOI 10.3389/fonc.2022.873722
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →