CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
基于细胞的疗法在慢性移植物抗宿主病的预防和治疗中的应用
英文原题：Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease.
查看英文原题
Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease.
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中文摘要
异基因造血干细胞移植（allo-SCT）是血液系统恶性肿瘤患者的治愈性选择。然而，由于供者与受者之间主要和次要组织相容性抗原的差异，可能发生严重的炎症并发症，其中慢性移植物抗宿主病（cGVHD）可危及生命。预防和治疗cGVHD的经典治疗方法是广泛免疫抑制，但最近已开始测试辅助免疫疗法。本综述总结并讨论了基于T细胞的免疫调节方法，包括嵌合抗原受体（CAR）T细胞和调节性T细胞，基于自然杀伤（NK）细胞和固有淋巴样细胞（ILC）的方法，以及最后基于间充质基质细胞（MSC）及其细胞外囊泡的方法。临床研究和临床前研究结果同样予以呈现。
展开英文摘要原文
Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies.
However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory complications can occur, among which chronic graft-versus-host disease (cGVHD) can be life-threatening. A classical therapeutic approach to the prevention and treatment of cGVHD has been broad immunosuppression, but more recently adjuvant immunotherapies have been tested.
This review summarizes and discusses immunomodulatory approaches with T cells, including chimeric antigen receptor (CAR) and regulatory T cells, with natural killer (NK) cells and innate lymphoid cells (ILCs), and finally with mesenchymal stromal cells (MSC) and extracellular vesicles thereof. Clinical studies and pre-clinical research results are presented likewise.
论文信息
- 作者
- Doglio M、Crossland RE、Alho AC、Penack O、Dickinson AM、Stary G、Lacerda JF、Eissner G
- 第一作者单位
- Experimental Haematology Unit, Division of Immunology Transplantation and Infectious Diseases, Vita-Salute San Raffaele University, Milan, Italy.Italy
- 通讯作者单位
- Department of Pharmacology, University of Oslo and Oslo University Hospital, Oslo, Norway.Norway
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Frontiers in immunology2022
- 原文标识
- PubMed 36466922 · DOI 10.3389/fimmu.2022.1045168
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →