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肿瘤免疫治疗的局限性

英文原题:Limitations of Immunotherapy in Cancer.

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Limitations of Immunotherapy in Cancer.

PubMed 2022/10/29(内容时间) Cureus

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中文摘要

尽管药物治疗取得重要进展,癌症仍是全球主要死亡原因之一。针对恶性肿瘤的免疫疗法不断发展,为这一难题带来新的治疗希望。现代免疫治疗药物迅速发展,使部分难治性恶性肿瘤的治疗效果改善,患者生存也有所延长。然而,这些治疗仍面临重大障碍:临床应答存在差异,尤其是靶向免疫检查点抑制、嵌合抗原受体(CAR)T细胞疗法、溶瘤病毒和重组细胞因子等疗法;肿瘤细胞会利用多种机制逃避免疫监视。其他挑战还包括难以预测疗效及患者应答、缺乏更多生物标志物、治疗后可能出现针对免疫治疗的免疫反应、缺少用于判定治疗充分性的现代化临床评估方案,以及治疗费用高昂。本文综述中期恶性肿瘤治疗,并探讨免疫疗法面临的五项主要困难、挫折和局限。

展开英文摘要原文

Despite primary advancements in medication, cancer continues to be one of the main reasons for death globally. Techniques for immunotherapy against malignant improvement are rising as fantastic treatments for this setback. The rapid development of modern immunotherapeutics has inspired a decrease in stubborn malignancies and led to an emotional improvement in patient endurance.

However, a giant barrier to these ongoing treatment modalities is an anomaly in clinical response, specifically articulated amongst targeted spot inhibition, chimeric antigen receptor (CAR) T-cell therapy, oncolytic infections, and recombinant cytokines emerging since sickness cells use a variety of structures to avert immunosurveillance.

Other challenges encompass the lack of ability to predict the efficacy of the therapy and the response of the patient, the want for additional biomarkers, the improvement of immunity in opposition to malignant boom immunotherapies, the absence of medical assessment plans that are up-to-date to decide sufficiency, and high therapy costs. The therapy for middle-stage malignant growth and the top five difficulties, setbacks, and drawbacks of immunotherapy are examined in this audit.

论文信息

作者
Gupta S、Shukla S
单位
Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, IND.
文献类型
综述
期刊
Cureus2022 Oct
原文标识
PubMed 36465776 · DOI 10.7759/cureus.30856